http://sciencedaily.i2p/releases/2021/10/211015133212.htm
But, the scientists believed, this was an effect of obesity, due to the mice being less active, rather than a cause. "Overall, we think overeating due to leptin resistance was the driving cause behind why these mice became obese," said Dr. Yanagiya. To further investigate how loss of XRN1 results in leptin resistance and an increased appetite, the scientists looked at whether the activity of appetite-regulating genes changed within the hypothalamus.